Antimicrobial potential


International Journal of Molecular Sciences. 2023; 24(3):2389.

Article name

Cannabidiol and Cannabigerol Exert Antimicrobial Activity without Compromising Skin Microbiota


Luz-Veiga, M.; Amorim, M.; Pinto-Ribeiro, I.; Oliveira, A.L.S.; Silva, S.; Pimentel, L.L.; Rodríguez-Alcalá, L.M.; Madureira, R.; Pintado, M.; Azevedo-Silva, J.; et al.

Antimicrobial Effects of CBD and CBG Without Harming Skin Microbiota

Cannabinoids are substances found in the Cannabis sativa plant. Two of them, cannabidiol (CBD) and cannabigerol (CBG), have been found to have various beneficial effects, including antimicrobial activity. This means they can kill or slow down the growth of bacteria and other microorganisms.

About the Study

This study, conducted by João Fernandes and his team, is a laboratory-based research that delves into the antimicrobial properties of CBD and CBG. It focuses on how these cannabinoids interact with certain microorganisms that are commonly associated with skin conditions.

The Researchers and Their Institution

The study was conducted by a team of researchers led by João Fernandes. The research was published in the International Journal of Molecular Sciences, a reputable scientific journal.

Main Findings

  • CBD and CBG demonstrated strong antimicrobial activity against various bacteria and fungi.
  • Both cannabinoids were effective in inhibiting the formation of biofilms, a group of microorganisms where cells stick to each other on a surface.
  • CBG showed higher activity than CBD in inhibiting the adhesion of Staphylococci to keratinocytes (skin cells).
  • CBG met the criteria for antimicrobial effectiveness in cosmetic formulations.

Methodology: How the Research Was Conducted

The research was conducted in a laboratory over several weeks. The team used pure samples of CBD and CBG to test their antimicrobial activity against various microorganisms. They measured the minimum inhibitory concentrations (MICs) and minimum lethal concentrations (MLCs), which are the lowest concentration of an antimicrobial that prevents visible growth of a microorganism and kills the microorganism, respectively. They also tested the ability of these cannabinoids to inhibit the formation of biofilms and their effect on the adhesion of Staphylococci to keratinocytes.

Potential Implications

The findings of this study suggest that CBD and CBG could be promising agents for topical antimicrobial treatments. They could potentially be used in the treatment of various skin conditions, and CBG could be used as a preservative in cosmetic products.

You can find the study here.

What are the Limitations of this Study?

While the study provides valuable insights, it's important to note that it was conducted in a laboratory setting, not on actual human skin. Therefore, further research is needed to confirm these findings in clinical trials.


This study highlights the potential of CBD and CBG as antimicrobial agents. Their ability to inhibit the growth of harmful microorganisms without disrupting the skin's natural microbiota makes them promising candidates for the development of new treatments for skin conditions.


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