Review of Literature



International Journal of Molecular Sciences 23, no. 24: 16181.

Article name

Advances and Challenges of Cannabidiol as an Anti-Seizure Strategy: Preclinical Evidence


Zavala-Tecuapetla, Cecilia, Hiram Luna-Munguia, María-Leonor López-Meraz, and Manola Cuellar-Herrera.

Exploring Cannabidiol's Potential as an Anti-Seizure Strategy: A Review of Preclinical Evidence

The use of cannabis for medicinal purposes has been documented since ancient times. One of its principal cannabinoids, cannabidiol (CBD), has emerged as a promising molecule with anti-seizure potential. This article delves into a recent scientific study conducted by researchers from various institutions in Mexico, including the National Institute of Neurology and Neurosurgery, the Universidad Nacional Autonoma de Mexico, the Universidad Veracruzana, and the Hospital General de México Dr. Eduardo Liceaga.

The study is a review of literature, focusing on preclinical evidence of CBD's anti-seizure effects. The authors have meticulously analyzed various aspects of CBD, including its pharmacological profile, interactions with multiple molecular targets, and its potential therapeutic efficacy in epilepsy, especially drug-resistant epilepsy.

Main Findings:

  • CBD has multiple effects resulting from its actions on several molecular targets, making it a promising therapeutic agent for various diseases, including epilepsy.
  • Preclinical research supports CBD's anti-seizure effect on both acute seizure models and chronic models of epilepsy.
  • Other natural cannabinoids and synthetic derivatives of CBD are also being explored for their potential anti-seizure properties.


The study is a comprehensive review of existing literature, with the authors analyzing various research papers and studies conducted over the years. The duration of the research is not specified. The data was collected from various sources and analyzed to understand the potential of CBD as an anti-seizure agent. The study does not mention specific tools or materials used in the research. Information about dosing is also not provided as it is a literature review and not a clinical trial.

Potential Implications:

The study encourages further investigation into the therapeutic efficacy of CBD and its related compounds, not only in epilepsy but also in drug-resistant epilepsy. There is a dire need for new and effective drugs to treat this disease, and CBD could potentially fill this gap.


As a literature review, the study does not provide first-hand data or experimental results. It relies on the findings of other researchers. Therefore, the conclusions drawn are based on the interpretation of existing data and may be subject to the limitations of the original studies.


The study concludes that CBD, due to its interaction with multiple molecular targets and its demonstrated anti-seizure effect in preclinical research, holds promise as a potential therapeutic agent for epilepsy, especially drug-resistant epilepsy. However, more research is needed to fully understand its efficacy and safety profile.


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