Antimicrobial potential


Scientific reports, 12, 6454 (2022).

Article name

Potential cannabidiol (CBD) repurposing as antibacterial and promising therapy of CBD plus polymyxin B (PB) against PB-resistant gram-negative bacilli


Abichabki, N., Zacharias, L.V., Moreira, N.C. et al.

Potential of Cannabidiol (CBD) as an Antibacterial Agent

Antimicrobial resistance is a global health issue, with bacteria becoming increasingly resistant to the drugs designed to kill them. A recent study published in Nature explores the potential of cannabidiol (CBD), a non-psychoactive compound found in cannabis, as a new weapon in this fight.

What's the Study About?

The study, led by Leonardo N. Andrade, investigates the antibacterial properties of CBD, particularly in combination with polymyxin B (PB), an antibiotic used to treat infections caused by multidrug-resistant bacteria. The research was conducted in a laboratory setting, focusing on Gram-negative bacteria, which are often resistant to multiple drugs.

Who Conducted the Study?

Leonardo N. Andrade and his team carried out this research. The details of the institution where the study was conducted are not provided in the abstract.

Main Findings

  • CBD showed antibacterial activity against Gram-positive bacteria and certain Gram-negative bacteria.
  • When combined with PB, CBD demonstrated antibacterial activity against Gram-negative bacteria, including those resistant to PB.
  • The combination of CBD and PB led to a greater reduction in the number of bacteria compared to CBD and PB alone.

How Was the Study Conducted?

The researchers used standard broth microdilution methods, checkerboard assays, and time-kill assays to conduct their study. They tested the antibacterial activity of CBD alone and in combination with PB against a variety of bacteria. The specific dosing details were not provided in the abstract, but the researchers tested various concentrations of CBD and PB.

What Could This Mean for the Future?

This study suggests that CBD has potential as an antibacterial agent, especially when used in combination with other antibiotics like PB. This could open up new avenues for treating infections caused by drug-resistant bacteria.

What are the Limitations of this Study?

As the study was conducted in a lab, further research is needed to determine whether these findings would hold true in a clinical setting. Additionally, the study did not provide specific details about the dosing of CBD and PB, which would be important for understanding how to use these substances in a real-world context.


The study provides promising evidence of the antibacterial properties of CBD, particularly in combination with PB. However, further research is needed to confirm these findings and to explore the potential of CBD as a treatment for drug-resistant bacterial infections.


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