Cervical cancer


Integrative Cancer Therapies. 2022;21

Article name

Enhancement of Conventional and Photodynamic Therapy for Treatment of Cervical Cancer with Cannabidiol


Razlog R, Kruger CA, Abrahamse H.

Enhancing Cervical Cancer Treatment with Cannabidiol and Photodynamic Therapy: A Review

Cervical cancer, the fourth most diagnosed cancer in women worldwide, often presents a challenge due to its resistance to conventional treatments and its ability to metastasize. This article reviews a scientific study conducted by Radmila Razlog, Cherie Ann Kruger, and Heidi Abrahamse from the University of Johannesburg, South Africa, which explores the potential of combining conventional treatments with cannabidiol (CBD) and photodynamic therapy (PDT) to enhance the effectiveness of cervical cancer treatment.

The study is a literature review, meaning it synthesizes and analyzes existing research rather than conducting new experimental research. The authors focus on the potential of CBD, a compound derived from cannabis, in conjunction with PDT, a treatment that uses light to kill cancer cells.

Main Findings

  • CBD has shown in vitro anticancer effects against cervical cancer, inducing apoptosis (cell death) and specific immune responses that hinder tumor invasion and metastasis.
  • PDT has demonstrated clinical evidence of eradicating primary cervical cancer and limiting secondary metastasis.
  • The combination of CBD and PDT could potentially prevent cervical cancer's secondary migration.


The authors conducted an extensive review of the literature published over the last 10 years. They analyzed data from various studies, focusing on the effects of CBD and PDT on cervical cancer. The review did not involve direct interaction with patients or the administration of CBD or PDT. Instead, it relied on the results of previous studies, including information about dosing and the effects of these treatments on cancer cells.

Potential Implications

The findings suggest that combining CBD and PDT could offer a more effective treatment for cervical cancer. This combination could potentially overcome the limitations of conventional treatments, particularly in relation to cancer's resistance to treatment and its aggressive metastatic nature.


While the review presents promising findings, it also acknowledges the need for further research. The authors note that more clinical trials are needed to refine the delivery and dosing of PDT and to improve its ability to activate specific immune responses. The potential use of CBD as a treatment for cervical cancer also needs careful research, given that some studies have suggested that other cannabis compounds might promote the progression of certain cancers.


The study concludes that the combination of CBD and PDT could potentially enhance the effectiveness of cervical cancer treatment. However, further research is needed to confirm these findings and to ensure the safe and effective use of these treatments. The authors encourage future research to focus on this synergistic effect to eradicate cervical cancer.

For more details, you can read the full study here.


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