Animal study



SCIENCE ADVANCES, Vol 8, Issue 8, 2022

Article name

Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate immune responses


Long Chi Nguyen, Dongbo Yang, Vlad Nicolaescu, Thomas J. Bes, Haley Gula, Divyasha Saxena, Jon D. Gabbard, et. al.

Cannabidiol: A Potential Weapon Against COVID-19

Conducted by a team of researchers led by Long Chi Nguyen and Marsha Rich Rosner, this study explores the potential of cannabidiol (CBD) in inhibiting the replication of SARS-CoV-2, the virus responsible for COVID-19. The research was carried out at the University of Chicago and published in Science Advances in January 2022.

What Did the Researchers Discover?

  • CBD, a compound found in the cannabis plant, can prevent and inhibit SARS-CoV-2 infection.
  • CBD acts after the virus has entered the host, inhibiting viral gene expression and reversing many effects of SARS-CoV-2 on host gene transcription.
  • CBD's metabolite, 7-OH-CBD, also showed potent antiviral activity.

How Did They Conduct the Research?

The research was conducted in vitro using human lung carcinoma cells. The cells were treated with CBD before being infected with SARS-CoV-2. The researchers then monitored the cells for expression of the viral spike protein and viral titer. The study also involved the use of RNA sequencing to analyze the effects of CBD on cellular gene expression.

What Could This Mean for the Future?

The findings of this study suggest that CBD could be used as a preventative agent for early-stage SARS-CoV-2 infection. However, the researchers caution against the current use of non-medical formulations as a preventative or treatment therapy.

What are the Limitations of this Study?

While the study presents promising results, it's important to note that the research was conducted in vitro, not in humans. Further clinical trials are needed to confirm these findings.


This study highlights the potential of CBD as a preventative agent against SARS-CoV-2 infection. However, more research is needed to fully understand its efficacy and safety in humans.

For more details, read the full study here.


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