Review of Literature

Rheumatic Diseases


Rambam Maimonides Med J. 2020 Jan; 11(1): e0007

Article name

Treatment of Rheumatic Diseases with Cannabis and Cannabinoids


Gonen T, Amital H

Cannabis and Cannabinoids in the Treatment of Rheumatic Diseases

Chronic pain is a common issue among patients, and rheumatic diseases are a frequent cause. Current pharmacological interventions for chronic pain are not always effective or safe for long-term use. This has led to the exploration of alternative treatments, such as cannabis and cannabinoids, for their potential as analgesics. A recent study titled "Cannabis and Cannabinoids in the Treatment of Rheumatic Diseases" delves into this topic.

The study is a review of literature conducted by researchers from the Rambam Maimonides Medical Journal. It focuses on the potential of using cannabis and cannabinoids in the treatment of rheumatic diseases, including fibromyalgia, a prevalent rheumatic disease that causes diffuse pain, fatigue, and sleep disturbances.

Main Findings

  • Cannabis and cannabinoids could potentially alleviate some of the symptoms associated with fibromyalgia.
  • There is evidence of the potential immune-modulatory effect of cannabinoids and cannabis, supported by results in animal models of certain rheumatic diseases.
  • Cannabis and cannabinoids remain potential drugs to alleviate the pain associated with rheumatic diseases.


The study is a review of literature, meaning the researchers analyzed and synthesized various studies on the topic. The duration of the research is not specified in the study. The data was collected from various studies and analyzed to draw conclusions. No specific tools or materials were used in the research, and information about dosing was not applicable in this case.

Potential Implications

The study suggests that cannabis and cannabinoids could potentially be used to alleviate the pain associated with rheumatic diseases. This could provide an alternative treatment for patients who do not respond to traditional pharmacological interventions.


While the study provides promising insights, it acknowledges that data on the long-term efficacy and safety of cannabinoid and cannabis use are still lacking. More research is needed to confirm these findings and to explore the potential side effects and risks associated with long-term use.


The study concludes that while more research is needed, cannabis and cannabinoids show potential as an alternative treatment for the pain associated with rheumatic diseases. The researchers recommend further exploration of cannabis and cannabinoids as a repurposed therapeutic agent in clinical trials.

For more detailed information, you can read the full study here.


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