Human study

Emotional Exhaustion and Burnout


JAMA Netw Open. 2021;4(8):e2120603

Article name

Efficacy and Safety of Cannabidiol Plus Standard Care vs Standard Care Alone for the Treatment of Emotional Exhaustion and Burnout Among Frontline Health Care Workers During the COVID-19 Pandemic: A Randomized Clinical Trial


Crippa JAS, Zuardi AW, Guimarães FS, et al.

CBD for Treating Burnout Among Healthcare Workers

The COVID-19 pandemic has put an enormous strain on healthcare workers worldwide, leading to high levels of emotional exhaustion and burnout. This article discusses a study that investigated the use of cannabidiol (CBD), a compound found in cannabis, as a potential treatment for these issues.

About the Study:

The study was a randomized clinical trial conducted by a team of researchers from various institutions, including the University of São Paulo, Brazil. It aimed to assess the safety and efficacy of CBD, in addition to standard care, versus standard care alone for treating emotional exhaustion and burnout symptoms among frontline healthcare professionals working with COVID-19 patients.

Main Findings:

  • The study found that CBD, when used alongside standard care, was more effective in reducing emotional exhaustion and burnout symptoms than standard care alone.
  • The treatment was generally well-tolerated, with some side effects such as liver enzyme elevation, pharmacodermia, and weight gain reported.


The study was conducted over a period of four weeks. Data was collected through various subjective scales, blood tests, and analysis of plasma levels of CBD. The dose of CBD received by the study subjects was not explicitly mentioned in the article.

Potential Implications:

The findings of this study suggest that CBD could be a potential treatment option for healthcare workers experiencing emotional exhaustion and burnout, particularly in high-stress situations like the current pandemic.


The study was not blinded, which could introduce bias. The article did not specify aspects inherent to the work style of the study participants, such as workload, work shift, and the function performed by each professional in the hospital context.


While further research is needed, this study provides promising evidence for the use of CBD in treating emotional exhaustion and burnout among healthcare workers. It is crucial to consider these findings in the context of the ongoing mental health crisis among healthcare professionals due to the COVID-19 pandemic.

Link to the study: Cannabidiol for the Treatment of Emotional Exhaustion Among Frontline Health Care Workers


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