Human study

Blood pressure


JCI Insight. 2017 Jun 15;2(12):e93760. doi: 10.1172/jci.insight.93760. PMID: 28614793; PMCID: PMC5470879

Article name

A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study


Jadoon KA, Tan GD, O'Sullivan SE

A Single Dose of CBD Can Reduce Blood Pressure, Says Study

Cannabidiol (CBD) is a non-psychoactive compound found in cannabis plants. It's been gaining attention for its potential health benefits. One area of interest is its effect on blood pressure. High blood pressure can lead to serious health issues like heart disease, so finding effective treatments is crucial.

Introduction to the Study

This study, conducted by Khalid A. Jadoon, Garry D. Tan, and Saoirse E. O’Sullivan, is a human study that investigates the effects of a single dose of CBD on blood pressure. The researchers are affiliated with reputable institutions, and the study was published in the Journal of Clinical Investigation Insight.

Main Findings

  • CBD reduced resting systolic blood pressure.
  • CBD reduced the blood pressure response to stress.
  • CBD increased heart rate but maintained cardiac output.


The study involved nine healthy male volunteers who were given 600 mg of CBD or a placebo in a randomized, double-blind, crossover study. The researchers monitored cardiovascular parameters using a finometer and laser Doppler. The study was acute, meaning it was conducted over a short period, and the data was collected and analyzed using statistical methods.

Potential Implications

The results suggest that CBD could potentially be used as a treatment for high blood pressure, particularly in stressful situations. This could have significant implications for people suffering from hypertension and related cardiovascular disorders.

What are the limitations of this study?

The study was small, with only nine participants, all of whom were healthy males. Therefore, the results may not apply to a larger population, females, or people with existing health conditions. Further research is needed to confirm these findings and determine the long-term effects of CBD on blood pressure.


In conclusion, this study provides preliminary evidence that a single dose of CBD can reduce resting blood pressure and the blood pressure response to stress. However, more research is needed to fully understand these effects and their potential therapeutic applications.

A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study


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