Review of Literature

Migraine Treatment


Frontiers in Pharmacology, 9, 2018, DOI: 10.3389/fphar.2018.00420, ISSN=1663-9812

Article name

Emerging role of (endo)cannabinoids in migraine


Pinja Leimuranta, Leonard Khiroug, Rashid Giniatullin

Unraveling the Potential of Cannabinoids in Migraine Treatment

Migraines are debilitating headaches that can cause severe pain and other symptoms. They are a common health issue, affecting millions of people worldwide. Despite extensive research, the exact cause of migraines remains unclear, and current treatments are not always effective. This has led scientists to explore new avenues for treatment, including the use of cannabinoids, compounds found in the cannabis plant.

About the Study

The study we're discussing today is a review of literature conducted by Pinja Leimuranta, Leonard Khiroug, and Rashid Giniatullin. These researchers are affiliated with the University of Eastern Finland and the Kazan Federal University in Russia. Their research focuses on the role of cannabinoids in controlling the pain associated with migraines.

Main Findings

  • Cannabinoids could potentially treat migraines due to their anticonvulsive, analgesic, antiemetic, and anti-inflammatory effects.
  • The endocannabinoid system (ECS), a complex cell-signaling system in our bodies, plays a crucial role in maintaining body homeostasis and is involved in various functions, including pain sensation.
  • Disruptions in the ECS have been linked to migraines, suggesting that treatment with cannabinoids could help restore balance.
  • However, the use of cannabinoids in migraine treatment is complex and may have unwanted side effects, especially at higher doses.


The researchers conducted a comprehensive review of existing literature on the topic. They analyzed various studies that explored the role of cannabinoids and the endocannabinoid system in migraine treatment. The review was not limited to a specific time frame, allowing the researchers to include a wide range of studies.

Potential Implications

The findings of this review could have significant implications for migraine treatment. If further research supports these findings, cannabinoids could become a new treatment option for migraine sufferers. This could be particularly beneficial for patients who have not responded well to existing treatments.


The main limitation of this study is that it is a review of existing literature, rather than new experimental research. Therefore, the conclusions are based on the findings of previous studies, which may have their own limitations. Additionally, while the study suggests potential benefits of cannabinoids for migraine treatment, it also highlights the complexity of their use and the potential for unwanted side effects.


In conclusion, this study suggests that cannabinoids could potentially be used in the treatment of migraines. However, more research is needed to fully understand the implications of this treatment and to determine the most effective ways to use cannabinoids for this purpose.

You can read the full study here.


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