Human study

Exercise physiology.


Sports Medicine - Open 8, 27 (2022)

Article name

Effects of Cannabidiol on Exercise Physiology and Bioenergetics: A Randomised Controlled Pilot Trial


Sahinovic, A., Irwin, C., Doohan, P.T. et al.

Impact of Cannabidiol on Exercise Physiology: A Study Overview

Understanding the effects of substances on our bodies is crucial, especially when it comes to physical performance. A recent study, conducted by a team led by Danielle McCartney from the Lambert Initiative for Cannabinoid Therapeutics, University of Sydney, delves into the effects of Cannabidiol (CBD) on exercise physiology. Here's the study for your reference.

Unveiling the Study and Its Findings

This human study was a double-blind, placebo-controlled, cross-over trial involving nine healthy, recreationally active males. The key findings of the study are:

  • CBD appears to increase oxygen consumption (V̇O2) and pleasure during running.
  • No differences were observed in heart rate, perceived exertion, or blood glucose between treatments.
  • CBD seems to reduce concentrations of the endocannabinoid anandamide (AEA) post-running.

Peeking into the Methodology

The study was conducted over a period of several weeks. Participants were given either 300mg of oral CBD or a placebo 1.5 hours before exercise. They then performed two runs: a 60-minute run at a fixed intensity (70% V̇O2max) and a graded run to exhaustion. Various parameters were measured during the runs, including respiratory gases, heart rate, blood glucose and lactate concentrations, and perceived exertion. The data was collected and analyzed using a variety of tools and methods, including gas analysis systems and blood sampling.

Potential Implications of the Study

The results of this study suggest that CBD may alter some key responses to aerobic exercise without impairing performance. This could mean that CBD may be useful in the world of sports, particularly for endurance athletes.

What are the Limitations of this Study?

It's important to note that this was a pilot study with a small sample size. Therefore, further investigations with larger sample sizes are needed to confirm and better understand the findings.

Wrapping Up

While further investigations are needed, the findings of this study suggest that CBD may alter physiological and psychological responses to aerobic exercise. This opens up new avenues for understanding the potential role of CBD in sports and exercise.


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